SINUS HISTIOCYTOSIS WITH MASSIVE LYMPHADENOPATHY

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Abstract
This case report brings to attention an unusual form of massive benign lymphadenopathy which can simulate malignant lymphoma. The disease occurs mainly in children and is characterized by a protracted course with painless enlargement of the cervical lymph nodes, fever, leukocytosis, mild anemia, raised erythrocyte sedimentation rate and hypergammaglobulinemia. The diagnosis is confirmed by a quite distinct microscopic picture of the involved lymph nodes. SHML is considered to be an unusual response to an infection in an individual with abnormal host defense, though this is not confirmed by these investigations.