EFFECTS OF A T-ALLELE (TAE5) IN MOUSE ON LYMPHOID SYSTEM AND REPRODUCTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (OCT) , 443-451
Abstract
Mice homozygous for tAE5, a recessive allele at the complex T-locus, were characterized by their unique short-tailed phenotype as well as by runting and low fertility. Histological and histochemical studies of the lymphoid and reproductive systems disclosed structural changes in the mutant spleen resembling those found in autoimmune conditions. Involution of the mutant thymus was greatly accelerated compared to normal. Necrotic changes occurred during spermiogenesis whereas the ovarian structures were normal in mutants. The possible mechanisms of the mutant effects were discussed in the framework of other similar syndromes and the mode of action of alleles at the complex T-locus.