Age-dependent differences of distribution and clearance patterns in normal RIHSA cisternograms

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Abstract
In a retrospective study of 536 unselected consecutive RIHSA cisternographies a total of 84 cases with normal time-sequential scans were reviewed and, after dividing into three age groups, statistically elaborated with regard to the CSF pathways and flow rate. Our findings on a 5% level of significance are: 1) The total CSF flow and turnover depends on age; the highest rate of CSF flow is found in young patients (<25 years) and decreases constantly with increasing age. 2) In old patients (<50 years) the dorsal and lateral CSF pathways predominate over the frontomedial ones which are preferred in the younger age group (<25 years). 3) The washout of the basal cisterns and the clearance of the isotope over the convexities decreases significantly with increasing age. 4) The normal individual cisternographic variations and significant age-dependent differences agree with simultaneous encephalographic findings