Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock
Open Access
- 16 December 2002
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 21 (58) , 9043-9056
- https://doi.org/10.1038/sj.onc.1205958
Abstract
Blue light governs a number of cellular responses in bacteria, plants, and animals, including photoreactivation, plant development, and circadian photoentrainment. These activities are mediated by a family of highly conserved flavoproteins, the photolyase/cryptochrome family. Photolyase binds to UV photoproducts in DNA and repairs them in a process called photoreactivation in which blue light is used to initiate a cyclic electron transfer to break bonds and restore the integrity of DNA. Cryptochrome, which has a high degree of sequence identity to photolyase, works as the main circadian photoreceptor and as a component of the molecular clock in animals, including mammals, and regulates growth and development in plants.Keywords
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