Differential Distribution of Enzyme Hydrolyzing Acetylsalicylic Acid (Aspirin) in Certain Fluids of the Rat.

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Abstract
The object of the study was to determine whether there are differences in rates of in vitro production of salicylic acid when aspirin is incubated in the presumable immediate fluids of contact after gastrointestinal absorption in the rat (i.e., abdominal thoracic duct lymph and portal vein blood) as contrasted with systemically circulating blood obtained by heart puncture. During a two-hour period, with aliquot withdrawals at twenty-minute intervals, enzymatic hydrolysis of aspirin proceeded approximately only one-half as fast in the lymph as in the heart''s blood.