Synthesis of 2′- and 3′-Ketoadenosines
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 2 (3) , 275-289
- https://doi.org/10.1080/07328318308078861
Abstract
Both 2′- and 3′-ketoadenosines were prepared by the Pfitzner-Moffatt oxidation of the respective N 6-(4-monomethoxytrityl)-3′,5′-di-O-(4-monomethoxytrityl)- and N 6-(4-monomethoxytrityl)-2′,5′-di-O-(4-monomethoxytrityl)adenosines, followed by removal of the protective groups under anhydrous acidic conditions in chloroform. The products so obtained were stable at least to short-term storage at -2θ°C. Solution half lives for 2′-ketoadenosine and 3′-keto-adenosine were found to be ca. 11 h and ca. 84 h, respectively at 25 °C and pH 6.86.This publication has 17 references indexed in Scilit:
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