Barbiturate Dependence in Mice: Effects of Propranolol on the Withdrawal Syndrome
- 1 April 1980
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 163 (4) , 469-472
- https://doi.org/10.3181/00379727-163-40798
Abstract
C57BL/6J mice were made physically dependent on phenobarbital by means of a powdered diet mixed with the drug. During withdrawal, propranolol was found to reduce the frequency of seizures, while no effect was seen on other signs of withdrawal from barbiturates. Propranolol appears to be an effective anticonvulsant with respect to withdrawal-induced seizures.This publication has 4 references indexed in Scilit:
- Barbiturate withdrawal and magnesium deficiency in micePsychopharmacology, 1978
- Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal.Journal of Studies on Alcohol, 1977
- Studies on the contribution of active metabolites to the anticonvulsant effects of propranololEuropean Journal of Pharmacology, 1977
- Barbiturate dependence in mice: Effects of continuous vs. Discontinuous drug administrationPsychopharmacology, 1977