Relative Role of Cortisone and Growth Hormone on Glucose Intolerance and Insulin Secretion in Rat

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Abstract
A comparative study on the effects of cortisone and growth hormone (GH) on the glucose tolerance and insulin secretion in the rat was made by administering cortisone acetate daily for 28 days to five control and five MtT-W15 tumor-bearing hypersomatotropic Wistar/Furth female rats. After 28 days of cortisone treatment the control rats had a diabetic type of blood glucose response to an OGTT and the typical hyperinsulinemia of steroid diabetes, whereas the hypersomatotropic rats had a normal glucose tolerance and an extreme hyperinsulinemia both fasting and after glucose stimulation. Pancreatic insulin content and islet volume were above normal in both groups. The results suggest that cortisone but not GH impairs glucose tolerance in the rat. 1 Supported by Grant MT-1202 from the Medical Research Council of Canada

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