COLLAGEN CONTENT OF HUMAN AMNIOTIC MEMBRANES - EFFECT OF GESTATION LENGTH AND PREMATURE RUPTURE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (4) , 487-489
Abstract
Collagen content of amniotic membranes was measured in samples obtained at delivery from patients with and without premature rupture of the membranes (PROM). In samples from patients with PROM the collagen content (343 .mu.g/mg) was significantly lower than in samples from patients without PROM (373 .mu.g/mg) (P < 0.005). Collagen content decreased between 32 and 40 wk gestation from 446 to 362 .mu.g/mg (r = - 0.588; P < 0.001) in patients without PROM and from 393 to 332 .mu.g/mg (r = - 0.362; P < 0.05) in patients with PROM. The latent period between membrane rupture and delivery was not associated with a decrease in collagen content. Weakening of the amnion in preparation for rupture may be determined partly by factors controlling the synthesis and degradation of collagen.

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