A brain serine/threonine protein kinase activated by Cdc42 and Rac1
- 6 January 1994
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 367 (6458) , 40-46
- https://doi.org/10.1038/367040a0
Abstract
A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.Keywords
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