Structural rearrangements of chromosome Nr 8 involving 8q12?a primary event in pleomorphic ademona of the parotid gland
- 31 May 1987
- journal article
- research article
- Published by Springer Nature in Genetica
- Vol. 72 (2) , 85-92
- https://doi.org/10.1007/bf00123166
Abstract
Nine pleomorphic adenomas of the human parotid gland were investigated. Within this series the group of cases having clonal aberrations of chromosome Nr 8 predominates. The occurrence of cases with trisomy-8 and cases with structural rearrangements involving a breakpoint in 8q11-8q13 allows a further subdivision of this group of tumors. Our special interest in this paper is devoted to the latter group. the hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12. The translocations to different recipient chromosomes may serve as sign posts to transcriptionally active chromosomal domains in the salivary gland.Keywords
This publication has 12 references indexed in Scilit:
- Cytogenetics of the human benign mixed salivary gland tumourHereditas, 2008
- Chromosomal patterns in a benign human neoplasm, the mixed salivary gland tumourHereditas, 2008
- Aberrations of chromosome 8 in mixed salivary gland tumors—Cytogenetic findings on seven casesCancer Genetics and Cytogenetics, 1987
- The deleted long arm of chromosome 6: A secondary chromosome abnormality in solid tumors and lack of congenital aberrations monosomic for part of the critical segment?Cancer Genetics and Cytogenetics, 1985
- Further evidence for nonrandom chromosome changes in carcinoma cells—A report of 28 casesCancer Genetics and Cytogenetics, 1985
- Report of the committee on chromosome rearrangements in neoplasia and on fragile sitesCytogenetic and Genome Research, 1985
- Report of the committee on the genetic constitution of chromosome 1Cytogenetic and Genome Research, 1984
- NONRANDOM CHROMOSOMAL CHANGES IN TRANSITIONAL CELL-CARCINOMA OF THE BLADDER1984
- SPECIFICITY AND IMPLICATIONS OF RING CHROMOSOMES AND DICENTRICS IN BENIGN MIXED SALIVARY GLAND TUMOURSActa Pathologica Microbiologica Scandinavica Series A :Pathology, 1983
- The mixed salivary gland tumor — A normally benign human neoplasm frequently showing specific chromosomal abnormalitiesCancer Genetics and Cytogenetics, 1980