The Effect of Schistosoma mansoni Infection on the Response of Mice to Salmonella enteritidis and Listeria monocytogenes

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Abstract
Mice that had a light, chronic infection with Schistosoma mansoni were superinfected by the intravenous and oral routes with Salmonella enteritidis or Listeria monocytogenes, and the course of infection was monitored by observation of the growth of the organisms in vivo, as well as by compilation of data on mortality. No increase in resistance was shown against the intravenously injected Salmonella. Despite extensive pathologic changes in the organs of mice infected with schistosomes, bacteria were cleared normally. Orally administered salmonellae eventually caused a more severe systemic infection with a rapid rise in counts in organs. Schistosome-infected mice, periodically challenged with Listeria, displayed an increased nonspecific resistance at two and eight weeks after the initiation of the helminthic infection, and a phase of decreased resistance late in the course of the schistosomiasis. The periods of increased resistance are probably the result of stimulation of the reticuloendothelial system by soluble schistosomal antigens that are known to be released at these times.

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