An Antigenic Relationship Between Kidney and Certa in Escherichia coli Strains

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Abstract
By means of double diffusion analyses supplemented with absorption experiments an antigenic relationship was shown between human kidney and three out of nine tested E.coli strains. Antiserum to bacteria of these strains (serotypes O2:K1:H4, O14:K7:H- and O22:K13:H1) precipitated with kidney antigen from three adults and one infant, and antiserum to human kidney precipitated with veronal buffer extract antigens from the 3 E.coli strains. The veronal buffer extract antigen from the O2 strain contained at least 2 such antigenic factors, one related to the O2 lipopolysaccharide and another which was present also in the O22 and the O14 strains in an antigenically identical or related form. No antigens related to the tested E.coli strains were found in spleen, liver or AB Rh( + ) red cells. A possible significance of this antigenic relationship between kidney and some E.coli strains for the pathogenesis of the renal parenchymal reduction and scarring processes observed in some cases of pyelonephritis is proposed.

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