MATURATION-LINKED EXPRESSION OF C3B AND C3B' RECEPTORS ON DEVELOPING HUMAN-BONE MARROW AND PERIPHERAL-BLOOD GRANULOCYTES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 44  (1) , 201-210
Abstract
The sequential expression of granulocyte membrane receptors for C3b [complement component 3b], C3b'' and C3d were investigated in normal human bone marrow and peripheral blood. In particular the relationship between receptor expression and morphological characteristics of granulocyte maturation was assessed. Evidently C3b receptor development precedes that of the Fc-IgG receptor and is present on all neutrophil precursors with the exception of the agranular myeloblast. There is, in contrast to Fc-IgG receptors, no difference (P > 0.35) in C3b receptor expression between marrow and peripheral blood segmented neutrophils. An apparent subpopulation of granulocytes also appear to have receptors for C3b'', whereas receptors for C3d were not detected at all during granulocyte maturation. The application of these findings to the normal in vivo granulocyte functions and to the study of abnormal granulocyte populations in myeloproliferative disorders is discussed.