Faculty Opinions recommendation of Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

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Abstract
The immune synapse (IS) is a central event in the development of the adaptive immune response that results in the activation of the T cell. The specific signals that promote termination of the IS are unclear. This study found that, importantly, signaling molecules involved in the formation and function of the IS, e.g. PKCtheta, are also involved in synapse breakdown, constituting a possible mechanism of early remodeling of the IS. This Recommendation is of an article referenced in an F1000 Faculty Review also written by Alvaro Ortega-Carrion and Miguel Vicente-Manzanares.

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