Inhibitors of metabotropic glutamate receptors produce amnestic effects in chicks

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Abstract
Two antagonists of metabotropic glutamate receptors, L-AP4 and MCPG, were tested in a one-trial passive avoidance task in the chick to investigate whether these receptor subtypes play a role in learning and memory. Drugs were injected i.c. L-AP4 produced amnestic effects when injected pre- or post-training. When injected pretraining, amnesia onset was observed after 1 h post-training. D-AP4 had no effect on memory formation. MCPG in comparison had no effect when injected post-training. When injected pretraining, the onset of amnesia was dose-dependent, ranging from 2 to 1 h post-training. When injecting MCPG along with the mGluR agonist ACPD, no amnestic effect was visible. ACPD on its own had no effect at the dose used.

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