Continued Investigation Into the Influence of Loaded Dose on the Performance of Dry Powder Inhalers: Surface Smoothing Effects

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Abstract
The aerosolization of salbutamol sulfate, measured as fine particle dose (FPDLD) and fine particle fraction (FPFLD) (LD was observed at drug loadings between 10 and 63.5 μg and 10 and 135 μg for the surface dissolved and as supplied lactose monohydrates, respectively. Increasing the drug load above these levels resulted in linear increases in FPDLD with increasing drug load with the surface dissolved lactose monohydrate exhibiting higher FPDLD and FPFLD. This suggests that, at lower drug loadings, areas of the carrier exhibiting higher adhesion, so-called active sites, were being preferentially occupied and filled. Since there was no evidence of drug agglomeration using scanning electron microscopy, the observations suggest that the number and range of such higher energy “active sites” can be reduced by modifying the surface roughness, that is, energies, of the carrier.