OXOTREMORINE DOES NOT ENHANCE ACETYLCHOLINE RELEASE FROM RAT DIAPHRAGM PREPARATIONS
Open Access
- 1 September 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 70 (1) , 8-10
- https://doi.org/10.1111/j.1476-5381.1980.tb10897.x
Abstract
We have reinvestigated the dramatic effect of oxotremorine on acetylcholine release from the rat diaphragm reported by Das, Ganguly & Vedasiromoni (1978), using a rigorous gas chromatographic mass spectrometric/isotope dilution method for identification and measurement of acetylcholine and choline. Oxotremorine (10 μm) causes no significant change in the spontaneous or evoked (1 or 10 Hz) release or in the tissue levels of acetylcholine or choline.Keywords
This publication has 11 references indexed in Scilit:
- ENHANCEMENT BY OXOTREMORINE OF ACETYLCHOLINE RELEASE FROM THE RAT PHRENIC NERVEBritish Journal of Pharmacology, 1978
- The Effect of Atropine Upon Acetylcholine Release from Cat Superior Cervical Ganglia and Rat Cortical Slices: Measurement by a Radio-Enzymic MethodCanadian Journal of Physiology and Pharmacology, 1975
- PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE1Journal of Neurochemistry, 1975
- Inhibition by oxotremorine of acetylcholine resting release from guinea pig-ileum longitudinal muscle stripsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1975
- Simultaneous measurement of endogenous and deuterium-labeled tracer variants of choline and acetylcholine in subpicomole quantities by gas chromatography/mass spectrometryAnalytical Biochemistry, 1973
- Stimulating action of atropine on the release of acetylcholine by rat cerebral cortex in vitroBritish Journal of Pharmacology, 1971
- An Improved Synthesis of OxotremorineJournal of Medicinal Chemistry, 1965
- The identification of an active metabolite of tremorineBiochemical and Biophysical Research Communications, 1961