DIAZEPAM IN THE PROPHYLAXIS OF LIGNOCAINE SEIZURES

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Abstract
Diazepam 0.05–0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24–34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animakj the unimals appeared to be drowsy. However, prior administration of diazepam masked this effect. Convulsions were controlled by smaller doses of diazepam in non-treated animals than in diazepam-treated animak Also, the animals that were pretreated with diazepam had a greater duration of depression after seizure.

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