AORTIC DISSECTING ANEURYSMS - CAUSATIVE FACTORS IN 204 SUBJECTS

  • 1 January 1982
    • journal article
    • research article
    • Vol. 106  (4) , 175-180
Abstract
The pathogenesis of dissecting aneurysms of the aorta is controversial. The records of 204 patients with aortic dissecting aneurysms who underwent autopsy at the Johns Hopkins Hospital, Baltimore, Maryland, USA from 1889 to the present, and compared them with age-, race and sex-matched controls were reviewed. Hypertension, Marfan''s syndrome and traumatic, atherosclerotic or inflammatory injuries of the aortic media are factors associated with dissection. The gross and histologic findings and associated circumstances suggest that most spontaneous aortic dissections originate from tears of the inner layers of the aorta followed by intramural cleavage. In other patients, rupture of the intraaortic course of branch arteries for vasa vasorum may lead to dissection. No pathogenetic mechanism is common to all aortic dissections.

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