INDUCTION OF SUPPRESSION THROUGH HUMAN T-CELL INTERACTIONS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 39  (2) , 496-502
Abstract
Concanavalin (Con)A-activated T [thymus-derived] cells, devoid of cells bearing Fc receptors for Ig[immunoglobulin]G (T-TG), help human B [bone marrow-derived] lymphocytes to differentiate into plasma cells (PC) in response to pokeweed mitogen. PC differentiation is reduced when adult T cells are added to such cultures. The radiosensitivity of suppression and the radioresistance of help showed that adult T cells include a suppressor-precursor which is activated by irradiated Con A-precultured T cells. Newborn T cells which include active suppressors are poor stimulators of suppressor-precursors and poor helpers of B cells. At least 2 cells may mediate Con A-induced suppression, one which suppresses directly and is radiosensitive and another which is radioresistant and stimulates suppressor-precursors in a target population of T cells.

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