POSTSPLENECTOMY INFECTIONS IN DANISH CHILDREN SPLENECTOMIZED 1969–1978
- 1 July 1983
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 72 (4) , 589-595
- https://doi.org/10.1111/j.1651-2227.1983.tb09776.x
Abstract
From 1969-1978, 456 splenectomies in children 0-15 yrs old were registered in Denmark. The underlying disease in 56% was traumatic splenic rupture, in 20% hereditary spherocytosis, in 13% idiopathic thrombocytopenic purpura and in 11% various other disease; 384 (84%) were followed retrospectively for a mean period of 6.2 yrs after splenectomy. Twenty-one (5.5%) contracted bacteremia or meningitis, in 15 (71%) caused by Streptococcus pneumoniae, and 6 (1.6%) died from the infection. The frequency of postsplenectomy infection (PSI) was lower in children with splenic rupture (2.5%) than in those with hereditary spherocytosis (4.9%), idiopathic thrombocytopenic purpura (11.5%) and Hodgkin''s disease (13.8%); 16% of children splenectomized before the age of 4 yrs vs. 4% above that age developed PSI. Of the PSI cases, 95% occurred < 6 yrs after splenectomy. The incidence of severe pneumococcal bacteremia and pneumococcal meningitis in the splenectomized was 284 times that of non-splenectomized children.Keywords
This publication has 25 references indexed in Scilit:
- POSTSPLENECTOMY INFECTIONSThe Lancet, 1982
- Pneumococcal Disease after Pneumococcal VaccinationNew England Journal of Medicine, 1980
- Polyvalent Pneumococcal-Polysaccharide Immunization of Patients with Sickle-Cell Anemia and Patients with SplenectomyNew England Journal of Medicine, 1977
- SPLENECTOMY AND SUBSEQUENT MORTALITY IN VETERANS OF THE 1939-45 WARThe Lancet, 1977
- Sepsis and congenital aspleniaThe Journal of Pediatrics, 1977
- Overwhelming pneumococcal sepsis 25 years after splenectomyThe Lancet Healthy Longevity, 1975
- Bacteremia in febrile children under 2 years of age: Results of cultures of blood of 600 consecutive febrile children seen in a “walk-in” clinicThe Journal of Pediatrics, 1975
- Herpes zoster-varicella infection in malignant lymphomas. influence of splenectomy and intensive treatmentPublished by Elsevier ,1975
- Splenectomy in childhood: A review of 1413 casesJournal of Pediatric Surgery, 1972
- Relation Between Splenectomy and Subsequent Infection: A Clinical StudyArchives of Disease in Childhood, 1962