Suppression of platelet-derived growth factor α- and β-receptor mRNA levels in human fibroblasts by SV40 T/t antigen

Publisher Website
Google Scholar
Abstract
It is known that down-regulation of cell surface platelet-derived growth factor (PDGF) receptors accompanies transformation by SV40. In this work human embryonic lung fibroblasts were used as a model system to study the effects of SV 40 on PDGF receptor expression. It is shown that transformation by SV 40 early region leads to a total loss of PDGF α-receptor and partial loss of β-receptor mRNA. Microinjection experiments revealed that receptor down-regulation was a primary effect, and not only secondary to transformation and clonal selection. Total loss of PDGF α-receptor expression requires both large T and small t, and down-regulation of the PDGF α-receptor occurs independently of p53 and Rb binding to large T.

This publication has 64 references indexed in Scilit: