Negative Ventricular Diastolic Pressure in Beating Heart Studied in vitro and in vivo.

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Abstract
Recordings of the left ventricular diastolic and systolic pressure in the excised rat heart indicated that when the auricles were intact the excised heart beating in saline developed and maintained negative pressures during both systole and diastole. When the auricles were opened positive systolic and negative diastolic pressures were seen. This confirms the fact that the heart in diastole may develop a negative pressure and draw fluid into the ventricular chamber, subsequently ejecting the fluid on systole. Studies on the open chest dog revealed that although very small negative diastolic pressures are recorded by direct ventricular canulization, the negativity of the diastolic pressure is markedly increased by occluding the venous return. The left ventricle developed more negative pressure (15-25 mm of Hg) than the right ventricle (5-9 mm of Hg) during diastole. This is probably accounted for by the greater elastic recoil of the thicker left wall ventricle. Although the concept of the heart drawing fluid in during diastole is old, the magnitude of the negative pressure which can build up in diastole indicates that this mechanism may be more important in cardiac filling than has been considered in the past.

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