In Vitro Studies on the Radioresistance of Oxic and Hypoxic Cells in the Presence of Both Radioprotective and Radiosensitizing Drugs
- 1 September 1978
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 75 (3) , 563-572
- https://doi.org/10.2307/3574843
Abstract
In vitro studies involving CHO [chinese hamster ovary] monolayers demonstrated that the oxygenation status of the cells determines whether radioprotection or radiosensitization is observed when both Ro-07-0582 [1-(2-nitroimidazolyl)-3-methoxyisopropanol] (6 mM) and cysteine (8 mM) are present in the medium. This combination sensitizes hypoxic cells yet protects well-oxygenated ones. A comparison of individual drug effects on radiation resistance with those of the combination indicates that the latter can yield a larger therapeutic gain than either alone through reduction of drug toxicity and/or by improving relative tumor response.This publication has 0 references indexed in Scilit: