Intracellular λ Light Chain Inclusions in Chronic Lymphocytic Leukaemia
- 12 March 1978
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 38 (3) , 367-371
- https://doi.org/10.1111/j.1365-2141.1978.tb01056.x
Abstract
A [human] case of chronic lymphocytic leukemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of .lambda. L chain and were present in bone marrow derived (B) lymphocytes. The occurrence of L chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than was previously reported.Keywords
This publication has 14 references indexed in Scilit:
- A microculture technique in the evaluation of lymphocyte transformation by mitogens and specific antigens in humansIrish Journal of Medical Science, 1976
- Neutrophil function in gram-negative rod bacteremia. The interaction between phagocytic cells, infecting organisms, and humoral factors.Journal of Clinical Investigation, 1976
- Malignant Lymphoma with Intracytoplasmic IgM Crystalline InclusionsNew England Journal of Medicine, 1974
- Frequent Association of IgMλ with Crystalline Inclusions in Chronic Lymphatic Leukemic LymphocytesNew England Journal of Medicine, 1973
- Combined Studies of Complement Receptor and Surface Immunoglobulin-Bearing Cells and Sheep Erythrocyte Rosette-Forming Cells in Normal and Leukemic Human LymphocytesJournal of Clinical Investigation, 1973
- A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTESThe Journal of Experimental Medicine, 1972
- Binding of Sheep Red Blood Cells to a Large Population of Human LymphocytesNature, 1971
- A POPULATION OF LYMPHOCYTES BEARING A MEMBRANE RECEPTOR FOR ANTIGEN-ANTIBODY-COMPLEMENT COMPLEXESThe Journal of Experimental Medicine, 1970
- RAPID PREPARATION OF LYMPHOCYTES FOR TISSUE-TYPINGThe Lancet, 1969
- IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODSThe Journal of cell biology, 1961