Confirmation of a Tetrahydrocannabinol Metabolite in Urine by Gas Chromatography
- 1 January 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 6 (1) , 49-52
- https://doi.org/10.1093/jat/6.1.49
Abstract
A new method for confirming urinary 11-nor-Δ9-tetrahydrocannabinol-9-carboxylic acid, the major metabolite of tetrahydrocannabinol, has been developed. The metabolite is extracted, derivatized to the methyl ester, methyl ether, and analyzed on a gas chromatograph equipped with a flame ionization detector. In spiked urine specimens, metabolite concentrations as low as 20 ng/mL have been detected by this procedure. In a random sampling of urines, greater than 95% correlation was obtained between confirmation by this method and confirmation by gas chromatography/mass spectrometry in those specimens producing an immunological response greater than 75 ng/mL.This publication has 1 reference indexed in Scilit:
- Homogeneous enzyme immunoassay for cannabinoids in urine.Clinical Chemistry, 1978