Epinephrine Metabolism in Phenylketonuria.

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Abstract
Comparison of norepinephrine and epinephrine in plasma and of dopamine, norepinephrine, and epinephrine in urine of normal and phenylketonuric children revealed significantly lower levels of each in the phenylketonuric group (P < .001). These differences were reversed by treating phenylketonuric group with a diet low in phenylalanine. Since plasma tyrosine levels were unchanged, this difference appears to be caused by the inhibition of dopa decarboxylase by the derivatives of phenylalanine. This would provide further in vivo evidence that the pyridoxal-phosphate dependent decarboxylases represent related or identical enzyme systems.