Frontocortical N -acetylaspartate reduction associated with long-term IV heroin use
- 22 January 2002
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 58 (2) , 305-307
- https://doi.org/10.1212/wnl.58.2.305
Abstract
To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7% in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.Keywords
This publication has 11 references indexed in Scilit:
- Magnetic resonance spectroscopy in ADNeurology, 2001
- The neuropathology of heroin abuseForensic Science International, 2000
- Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin AbusersNeuropsychopharmacology, 2000
- Evidence for long-term neurotoxicity associated with methamphetamine abuseNeurology, 2000
- Letter to the EditorAddiction, 2000
- Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary reportDrug and Alcohol Dependence, 1999
- Gender Effects on Persistent Cerebral Metabolite Changes in the Frontal Lobes of Abstinent Cocaine UsersAmerican Journal of Psychiatry, 1999
- Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo1H magnetic resonance spectroscopyMagnetic Resonance in Medicine, 1998
- Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and WaterJournal of Magnetic Resonance, Series B, 1993