Studies on the Mechanism of Tachyphylaxis to Disodium Cromoglycate
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 55 (1-6) , 374-384
- https://doi.org/10.1159/000231948
Abstract
The tachyphylaxis to disodium cromoglycate’s (DSCG) inhibition of antigen-induced histamine release is readily demonstrable utilizing passively sensitized rat lung fragments. This tachyphylaxis to DSCG is evident whether or not calcium is present during drug preincubation. An attempt to relate the mechanism of tachyphylaxis to the DSCG-induced release of an endogenous cellular inhibitory material was unsuccessful insofar as could be demonstrated by an effect on mediator release.This publication has 2 references indexed in Scilit:
- Further Studies on the Tachyphylaxis to DSCGInternational Archives of Allergy and Immunology, 1977
- RELEASE OF HISTAMINE AND 5-HYDROXYTRYPTAMINE FROM CELLS OF THE PERITONEAL FLUID OF RATSCanadian Journal of Biochemistry and Physiology, 1961