Synaptic Proteins After Electroconvulsive Seizures in Immature Rats

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Abstract
The forebrain content of several rat brain synaptic proteins (synaptin, D1, D2 and D3) was reduced in rats receiving electroconvulsive seizures on days 2-11, 9-18 or 19-28 and sacrificed at 30 days old. Forebrain weight, total protein and the glial enzyme glutamine synthetase were decreased; the neuronal enolase 14-3-2 was unchanged. Seizures in the immature rat brain apparently resulted in a parallel reduction of synaptic material and of the amount of glial cells. The increased concentration of the enolase 14-3-2 found in rats seizured on days 19-28 may reflect the high demands on the glycolytic system during the seizures.