Synthesis of Enantiopure 1,2-Didehydropyrrolidine, D-Proline, and Oxazoline Derivatives via Staudinger-Aza-Wittig Cyclization of γ-Azido Aldehydes
- 1 January 1996
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1996 (01) , 123-132
- https://doi.org/10.1055/s-1996-4162
Abstract
The synthesis of 3-, 3,5- and 3,4,5-substituted prolines 1 and oxazolines 3 from inexpensive D-mannitol, employing the Staudinger-Aza-Wittig cyclization as a key step, is described.Keywords
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