STUDIES ON POLYPEPTIDES .29. SYNTHESIS OF THE N-TERMINAL TETRADECAPEPTIDE SEQUENCE OF RIBONUCLEASE-A, INCORPORATING BETA-(3-PYRIDYL)-L-ALANINE AT POSITION-12

  • 1 January 1979
    • journal article
    • research article
    • Vol. 13  (2) , 185-194
Abstract
The synthesis by fragment condensation of 12-(.beta.-3-pyridyl)Ala S-peptide (1-14), the 1-14 peptide sequence of ribonuclease A in which the histindine-12 residue is replaced by .beta.-(-pyridyl)-L-alanine, is described. The peptide binds strongly and stoichiometrically to S-protein; the resulting complex is enzymatically inactive.

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