THE GRAFT-VERSUS-HOST REACTIVITY IN AG-B/MLR DISPARATE STRAINS OF RATS

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Abstract
Inbred strains of rats can currently be classified into 8 Ag-B groups. Within an Ag-B group, individual strains generally share identity of the Ag-B histocompatibility antigens and mixed lymphocyte responses. In this report data is presented from 3 strains which are Ag-B and mixed lymphocyte reaction (MLR) disparate: KGH (Ag-B7, MLR-1) MNR (Ag-B4, MLR-5) and B3 (Ag-B3, MLR-4). Popliteal lymph node assays involving these 3 strains and standard inbred strains demonstrate that the graft vs. host reaction and MLR reactions in the rat are closely related. Positive graft vs. host reactions were observed only in strain combinations incompatible for the MLR and were unaffected by differences in their Ag-B histocompatibility antigens. The close association of the MLR and graft vs. host reaction provides additional evidence that the Ag-B/MLR disparity in these strains is the result of natural genetic recombinations within the major histocompatibility complex.

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