PLASMA LEVELS AND EXCRETION OF SOLVOLYZABLE STEROIDS

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Abstract
The faecal and urinary excretion of intravenously injected labelled dehydroepiandrosterone sulphate was studied in three healthy subjects on a standardized diet before and during oral cholestyramine administration. Faecal excretion was found to be an important pathway for the elimination of administered radioactivity. Thus, 28–45 per cent of the activity was recovered in the faeces during the control period. The urinary isotope excretion was slightly lower during cholestyramine administration. The plasma concentrations of »sulphates« of androsterone, dehydroepiandrosterone, epiandrosterone, androst-5-ene-3β,17β-diol and pregn-5-ene-3β,20α-diol and the urinary excretion of »sulphates« of the same steroids with the exception of epiandrosterone, were determined by gas chromatographic procedures. The individual and daily variations of the values were large and no change could be detected when cholestyramine was administered. The low renal clearance of steroid sulphates has been confirmed.

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