The metabolism of nicotine-Δ1′(5′)-iminium ion,in vivo andin vitro
- 1 October 1982
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 7 (4) , 293-298
- https://doi.org/10.1007/bf03189632
Abstract
Nicotine-Δ1′(5′)-iminium ion, either as the diperchlorate or the hydrochloride, is rapidly converted into cotinine by a hepatic cytoplasmic enzyme. Incubations in an atmosphere of nitrogen indicated that the oxygen incorporated into cotinine is derived from water. Following the intraperitoneal administration of nicotine-Δ1′(5′)-iminium ion to guinea pigs or rats, cotinine, and nicotine1′-N-oxide were found in the urine. The results support the idea that nicotine-Δ1′(5′)-iminium ion is an intermediate in the metabolic conversion of nicotine to cotinine.This publication has 13 references indexed in Scilit:
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