Inactivation of p16 , with Retention of pRB and p53/p21 Function, in Human MRC5 Fibroblasts That Overcome a Telomere-independent Crisis during Immortalization
Open Access
- 1 October 2004
- journal article
- Published by Elsevier
- Vol. 279 (42) , 43634-43645
- https://doi.org/10.1074/jbc.m402388200
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Alterations in the p16INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblastsOncogene, 2004
- Abolition of Cyclin-Dependent Kinase Inhibitor p16Ink4a and p21Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human FibroblastsMolecular and Cellular Biology, 2003
- Evidence That High Telomerase Activity May Induce a Senescent-like Growth Arrest in Human FibroblastsJournal of Biological Chemistry, 2003
- Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid FibroblastsMolecular and Cellular Biology, 2002
- Clonal Variation in Phenotype and Life Span of Human Embryonic Fibroblasts (MRC-5) Transduced with the Catalytic Component of Telomerase (hTERT)Experimental Cell Research, 2001
- Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of ProliferationExperimental Cell Research, 2000
- Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4aCell, 1997
- Specific Association of Human Telomerase Activity with Immortal Cells and CancerScience, 1994
- SV40-Transformed Human Cells in Crisis Exhibit Changes That Occur in Normal Cellular SenescenceExperimental Cell Research, 1994
- Telomeres shorten during ageing of human fibroblastsNature, 1990