Bronchiolitis obliterans organizing pneumonia associated with sulfasalazine in a patient with rheumatoid arthritis

24 February 2004

journal article
case report
Published by Springer Nature in Clinical Rheumatology

Vol. 23 (3) , 249-251
https://doi.org/10.1007/s10067-003-0848-5

Abstract

Pulmonary toxicity and blood dyscrasias are rare side effects of sulfasalazine. Pulmonary pathology is variable, the most common being eosinophilic pneumonia with peripheral eosinophilia, and interstitial inflammation with or without fibrosis. We here present the case of a 68-year-old female patient treated for 6 months with sulfasalazine for rheumatoid arthritis. On laboratory examination, eosinophil count was 97×10³ mm³. Thorocoscopic biopsy was performed . Histopathologic diagnosis was bronchiolitis obliterans organizing pneumonia (BOOP). This is the first case in the literature to present with sulfasalazine-induced BOOP in a patient with seronegative RA.

Keywords

This publication has 4 references indexed in Scilit:

Migratory pulmonary infiltrates in a patient with rheumatoid arthritis
Thorax, 2002
Sulphasalazine and lung toxicity
European Respiratory Journal, 2002
DRESS syndrome à la sulfasalazine et à la carbamazépine : à propos de deux cas
La Revue de Médecine Interne, 2001
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.
1992