A COMPARATIVE STUDY OF THE BLOOD CONCENTRATIONS AND URINARY EXCRETION OF SULFAPYRIDINE AND SULFANILAMIDE AFTER SINGLE DOSES OF SULFAPYRIDINE AND RELATED COMPOUNDS ADMINISTERED BY VARIOUS ROUTES
Open Access
- 1 January 1940
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 19 (1) , 201-213
- https://doi.org/10.1172/jci101111
Abstract
Glucose-sulfapyridine administered intraven. or subcut. gives high levels of the drug in the blood but is rapidly excreted and appears to circulate in a form which does not behave like sulfapyridine. The data for the clearances of glucose-sulfapyridine after its intraven. or subcut. adm. indicate that little or no reabsorption of glucose-sulfapyridine takes place. Glucose-sulfapyridine administered orally is absorbed slowly. In other respects, however, the drug present in the blood after its absorption from the gastro-intestinal tract behaves in the same manner as when sulfapyridine itself is given. Glucose-sulfapyridine given intraven. or subcut. does not enter the red blood cells, and is apparently distr. only in the extracellular fluids.This publication has 2 references indexed in Scilit:
- BACTERICIDAL ACTION OF SODIUM SULFAPYRIDINE AND OF A GLUCOSE-SULFAPYRIDINE SOLUTION IN HUMAN BLOODJournal of Clinical Investigation, 1940
- The Determination of SulfanilamideScience, 1938