On the Fate of DNA Synthesizing Lymphoid Blood Cells in Hodgkin's Disease
- 1 March 1975
- journal article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 14 (1) , 17-23
- https://doi.org/10.1111/j.1600-0609.1975.tb00289.x
Abstract
Autotransfusions of the DNA synthesizing blood cells from 2‐2.5 liters of blood, labelled in vitro with 3H‐thymidine, were performed in 2 patients with Hodgkin's disease. The fate of the labelled lymphoid cells was followed up for 5 min to 60 h in the circulating blood and occasionally in the lymph node tissue. The data indicate that 1) circulating DNA synthesizing large lymphoid cells leave the blood in less than 2 h; 2) they produce by mitosis large and medium sized lymphocytes, which mainly appear in blood and lymph nodes and 3) their generation time, in agreement with other estimates, is about 25 h.Keywords
This publication has 15 references indexed in Scilit:
- Autotransfusion of 3H-Cytidine-Labelled Blood Lymphocytes in Patients with Hodgkin’s Disease and Non-Hodgkin PatientsActa Haematologica, 1975
- Autotransfusion of 3H-Cytidine-Labelled Blood Lymphocytes in Patients with Hodgkin’s Disease and Non-Hodgkin PatientsActa Haematologica, 1975
- The thoracic duct lymph in Hodgkin's disease. II. Quantitative analysis of the cellular composition of the lymphInternational Journal of Cancer, 1971
- Depletion of lymphocytes for the protection of renal allograftsArchives of internal medicine (1960), 1970
- DNS-Synthese in Blut-Lymphozyten beim malignen LymphogranulomActa Haematologica, 1970
- Significance of the Changes in the Circulating Lymphoid Cells in Hodgkin's DiseaseBMJ, 1969
- Transformation, in vivo, of Basophilic Lymph Cells into Plasma CellsNature, 1967
- TRITIATED-THYMIDINE UPTAKE BY TUMOUR CELLS IN BLOODThe Lancet, 1964
- The route of re-circulation of lymphocytes in the ratProceedings of the Royal Society of London. B. Biological Sciences, 1964