STUDIES IN NICOTINIC ACID METABOLISM

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Abstract
It has not been possible to demonstrate nicotinic acid deficiency in man by the determination of either the blood level of nicotinic acid1 or the level of urinary excretion.2 The test described here is based on the level of excretion of nicotinic acid and trigonelline after a dose of nicotinamide. In dogs maintained on a diet low in nicotinic acid it has been shown that a dose of nicotinic acid is largely retained.3 After the dogs were well saturated by a high intake of nicotinic acid, most of the test dose of nicotinic acid was found in the urine as acid hydrolyzable nicotinic acid derivatives and trigonelline. This principle was applied to man in the following way: Twenty-four normal adults were instructed to omit for three days coffee, all leguminous vegetables and nuts (all of which contain trigonelline) from their otherwise adequate diets. On the evening of

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