Inhibition of hepatic lipogenesis by 2‐tetradecylglycidic acid
- 1 October 1979
- Vol. 14 (10) , 880-882
- https://doi.org/10.1007/bf02534133
Abstract
2‐Tetradecylglycidic acid (TDGA), a hypoglycemic agent, has been found to be a very effective inhibitor of de novo fatty acid synthesis by isolated hepatocytes. A comparison was made between the effectiveness of TDGA and 5‐(tetradecyloxy)‐2‐furoic acid (TOFA), a hypolipidemic agent, on the metabolic processes of isolated hepatocytes. These compounds are structurally related and both inhibit fatty acid synthesis; however, they have opposite effects from each other on the oxidation and esterification of fatty acids. TDGA inhibits whereas TOFA stimulates fatty acid oxidation. TDGA stimulates whereas TOFA inhibits fatty acid esterification.This publication has 12 references indexed in Scilit:
- Methyl 2-Tetradecylglycidate, An Orally Effective Hypoglycemic Agent that Inhibits Long Chain Fatty Acid Oxidation SelectivelyDiabetes, 1979
- Hormonal Control of Hepatic LipogenesisPublished by Springer Nature ,1979
- Evidence for a reciprocal relationship between lipogenesis and ketogenesis in hepatocytes from fed virgin and lactating ratsBiochemical Journal, 1978
- Pharmacologic profile of methyl 2-tetradecylglycidate (McN-3716)—An orally effective hypoglycemic agentMetabolism, 1978
- Inhibition of fatty acid synthesis by RMI 14,514 (5-tetradecyloxy-2-furoic acid)Biochemical and Biophysical Research Communications, 1978
- Inhibition by 5‐(tetradecyloxy)‐2‐furoic acid of fatty acid and cholesterol synthesis in isolated rat hepatocytesLipids, 1977
- Regulation of palmitate metabolism by carnitine and glucagon in hepatocytes isolated from fasted and carbohydrate refed ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1977
- Studies on the inhibition of hepatic lipogenesis by N6,O2′-dibutyryl adenosine 3′,5′-monophosphateArchives of Biochemistry and Biophysics, 1975
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969
- Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in bloodBiochemical Journal, 1962