The Complete Genome Sequence of Propionibacterium Acnes , a Commensal of Human Skin
Top Cited Papers
- 30 July 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 305 (5684) , 671-673
- https://doi.org/10.1126/science.1100330
Abstract
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes–associated diseases.Keywords
This publication has 17 references indexed in Scilit:
- The hyaluronate lyase of Staphylococcus aureus – a virulence factor?Microbiology, 2004
- A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive BacteriaInfection and Immunity, 2004
- Studies on the cytotoxic effects of Propionibacterium acnes strains isolated from corneaMicrobial Pathogenesis, 2003
- Characterization of Streptococcus agalactiae CAMP Factor as a Pore-forming ToxinPublished by Elsevier ,2003
- The Role of Innate Immunity in the Pathogenesis of AcneDermatology, 2003
- In situ localization of Propionibacterium acnes DNA in lymph nodes from sarcoidosis patients by signal amplification with catalysed reporter depositionThe Journal of Pathology, 2002
- Antigens of Mycobacterium tuberculosis Expressed during Preclinical Tuberculosis: Serological Immunodominance of Proteins with Repetitive Amino Acid SequencesInfection and Immunity, 2001
- Heat shock proteins and inflammatory acne vulgaris: molecular cloning, overexpression and purification of aPropionibacterium acnesGroEL and DnaK homologueFEMS Microbiology Letters, 2000
- Propionibacterium acnes, a resident of lipid-rich human skin, produces a 33 kDa extracellular lipase encoded by gehAMicrobiology, 1997
- Interaction of Propionibacterium acnes with skin lipids in vitroJournal of General Microbiology, 1993