Mechanisms of Actions of Inhaled Anesthetics
Top Cited Papers
- 22 May 2003
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (21) , 2110-2124
- https://doi.org/10.1056/nejmra021261
Abstract
“Suffering so great as I underwent cannot be expressed in words . . . but the blank whirlwind of emotion, the horror of great darkness, and the sense of desertion by God and man, which swept through my mind, and overwhelmed my heart, I can never forget.”1 Such was the experience of surgery before October 1846, when William Morton's successful public demonstration of ether anesthesia at Massachusetts General Hospital led to its widespread acceptance by surgeons. Today, anesthesiologists employ a wide variety of drugs, some of which they use exclusively to produce general anesthesia.2,3 This review focuses on the . . .Keywords
This publication has 121 references indexed in Scilit:
- The molecular mechanism of action of general anesthetics: structural aspects of interactions with GABAA receptorsToxicology Letters, 1998
- Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General AnestheticsAnesthesiology, 1997
- Central Nervous System Sodium Channels Are Significantly Suppressed at Clinical Concentrations of Volatile AnestheticsAnesthesiology, 1996
- Pontine Cholinergic Mechanisms Modulate the Cortical Electroencephalographic Spindles of Halothane AnesthesiaAnesthesiology, 1996
- Effects of Halothane on Glutamate Receptor-mediated Excitatory Postsynaptic CurrentsAnesthesiology, 1995
- Costs incurred by outpatient surgical centers in managing postoperative nausea and vomitingJournal of Clinical Anesthesia, 1994
- Differential Effects of Halothane, Enflurane, and Isoflurane on Ca2+Transients and Papillary Muscle Tension in Guinea PigsAnesthesiology, 1992
- Anesthetic Effects on Resting Membrane Potential Are Voltage-dependent and Agent-specificAnesthesiology, 1991
- Where do general anaesthetics act?Nature, 1978
- Zur Theorie der AlkoholnarkoseNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1899