Synthesis and antiinflammatory activity of trisubstituted pyrimidines and triazines

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Abstract
A series of mono-, bi-, and tricyclic pyrimidines and as-triazines was prepared and their antiinflammatory activity measured against carrageenan-induced edema in the rat. The more active analogs (ED50), including three 4-pyridylpyrimidines and 2-hydroxypyrimidine, were then tested against adjuvant-induced edema in the rat. None was active in the adjuvant arthritis model.

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