Enzyme Activities of Some Cultured Human Cells.

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Abstract
The activity of 3 enzymes in diploid and heteroploid human cells cultures derived from both normal and neoplastic tissues were compared. In general, acid phosphatase activity is similar in all of these cultures, although diploid cultures approaching or in phase III (decreased capacity for proliferation) may have higher activities of this enzyme. Alkaline phosphatase activity was high in the cultures derived from neoplastic tissue, and low in the diploid cultures derived from normal tissues.Cultures derived from normal tissues and transformed in vitro by an oncogenic virus show activities lower than any of the diploid cultures. Cultures derived from neoplastic tissues show lactate dehydrogenase activities 1.5- to 2-fold higher than the normal diploid or transformed cultures.

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