Plasma thromboxane B2, 6-KETO PGF1.ALPHA. and cyclic nucleotides levels as related to treadmill exercise test in patients with ischemic heart disease.

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Abstract
Plasma prostanoids and levels of cyclic nucleotides were studied in 49 outpatients with precordial pains and subjected to the treadmill exercise test. Blood samples were drawn before, immediately after and 30 min after exercise, from antecubital veins. Plasma TXB2 [thromboxane B-2], 6-keto PGF1.alpha. [6-keto-prostaglandin F1.alpha.] cAMP and cGMP levels were measured by radioimmunoassay. The results of exercise tests were evaluated according to the treadmill exercise score (TES) of Hollenberg et al. Patients were divided into 2 groups; those with TES (-) with ischemic findings in exercise and those with TES (+) with normal exercise response. There were no differences in TXB2 levels between the 2 groups before exercise. Immediately after exercise statistically significant differences in TXB2 levels were present between the 2 groups. There were increased levels in the TES (-) group and decreased levels in the TES (+) group (P < 0.01). Although the 6-keto PGF1.alpha. levels were the same between the 2 groups before exercise, 6-keto PGF1.alpha. levels in the TES (+) group increased significantly immediately after exercise. Similar changes were noted in the case of cyclic nucleotides, and the differences increased immediately after exercise. High responses of cyclic nucleotides and PGI2 are required to counteract increases in levels of TXA2 and diminution of these responses may be an important phenomenon involved in the physiological status of ischemic heart disease.