Local anesthetic effect of intrathecal normal saline

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Abstract
The effects of intrathecally administered normal saline [with procaine] were studied in patients undergoing graduated spinal anesthesia. The injection of 5 or 10 ml volumes resulted in segmental hypesthesia to pin-scratch and cold stimuli, extending from the lower thoracic to the sacral dermatomes. There was also partial sympathetic block evidenced by a diminished psychogalvanic skin reflex. The sites and possible mechanisms of action of saline are discussed; its use as placebo in graduated spinal anesthesia is questioned. Normal saline acts as a weak local anesthetic when injected intrathecally.