Abstract
Evidence is offered against the view that CO poisoning and anoxic anoxia are identical as to their physiological responses. Animals given mixtures of CO and O2 do not respond by a rise in blood pressure which is an invariable result of N administration. The absence of the rise is not due to any lack of capacity of the carotid sinus and aortic depressor nerve endings to receive stimuli: when the same concn. of CO is given with pure N rises in blood pressure are obtained. Animals recovering from anoxia produced in various ways usually attain blood pressure levels for a time greatly above the normal. The increased pressure occurred in vagotomized animals also, hence is not due solely to release from vagal inhibition.

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