Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysis

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Abstract
The ocular histopathological response of [complement] C3-depleted and normal DBA/2J mice was compared after corneal scarification and experimental infection with topically applied P. aeruginosa. Normal, non-C3-depleted mice mounted a vigorous polymorphonuclear leukocyte [PMN] response at 24 h after bacterial challenge and eventually restored corneal clarity. C3-depleted animals responded at 24 h to the ocular bacterial challenge with a decreased number of PMN migrating into the cornea. Additionally, the eyes of C3-depleted mice exhibited persistence of bacteria, cataract of the ocular lens and loss of vision.